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AssigneeSanraku-Ocean Co., Ltd.
InventorsToyokazu Nishino, Yasutaro Hamagishi, Toshikazu Oki, Sawao Murao
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New purine nucleoside 5'-phosphate (mono, di or tri) 3'(2')-diphosphates and the sodium, lithium and potassium salts thereof are elaborated by the enzymatic transfer of pyrophosphoryl group from ATP (adenosine triphosphate), dATP (deoxyadenosine triphosphate) and pppApp (adenosine 5'-triphosphate 3'(2') diphosphate) to specified 5'-purine nucleotides, and a new nucloetide pyrophosphotransferase used for this enzyme reaction is produced by actinomycetes and other microorganisms and recovered from the culture filtrate and mycelium by the conventional methods for recovering enzymes. These compounds are useful for treating leukemia L1210 in mice.
A purine nucleoside 5'-(mono, di or tri) phosphate 3'(2')-diphosphate and the corresponding purine nucleoside 5'-(di or tri) phosphate 3'(2')-monophosphate and the salts thereof selected from the group consisting of
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