Aralkyl carboxylic acid compounds
AssigneeTakeda Chemical Industries, Ltd.
InventorsHiroshi Morimoto, Isuke Imada, Masazumi Watanabe, Mitsuru Kawada
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Abstract
Novel compounds of the formulae ##STR1## wherein R represents lower alkyl or lower alkoxy, A represents --CH.sub.2 --, --CO-- or ##STR2## n represents an integer of 1 to 8, X represents hydrogen or hydroxyl which may be protected and Y represents hydroxyl which may be protected, and their esters show an excellent action on the lysosomal membranes of cells, and exhibit excellent pharmacological activities such as physiologic host defense control activity, especially immuno-potentiating activity.
Claims21
A compound selected from the group consisting of compounds of the formula ##STR15## wherein R represents alkyl of 1-4 carbon atoms or alkoxy of 1-4 carbon atoms, A represents --CH.sub.2 --, --CO-- or ##STR16## and n represents an integer of from 1 to 8 when A is --CO-- or ##STR17## when both A is --CH.sub.2 -- and R is alkoxy of 1-4 carbon atoms and an integer of from 4 to 8 when both A is --CH.sub.2 -- and R is alkyl of 1-4 carbon atoms,
- alkyl esters of said compounds wherein the alkyl moiety of said alkyl esters has 1-4 carbon atoms,
- aryl esters of said compounds wherein the aryl moiety of said aryl esters has 6-7 carbon atoms, and
- aralkyl esters of said compounds wherein the aralkyl moiety of said aralkyl esters has 7-8 carbon atoms,
- said alkyl, aryl amd aralkyl moieties of said esters being unsubstituted or substituted by at least one of sulfo, carboxyl, formyl, hydroxyl and amino.
Dependencies are inferred from the claim text.