P-Menthane carboxamides having a physiological cooling effect
AssigneeWilkinson Sword Limited
InventorsHugh R. Watson, David G. Rowsell, David J. Spring
Life of this patent
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Abstract
N-substituted-p-menthane-3-carboxamides are disclosed having the property of stimulating the cold receptors of the nervous system of the human body to produce a cold sensation and are used for this purpose in a variety of edible and topical preparations.
Claims12
In a consumer product for application to or consumption by the human body comprising a consumer product base and, as adjuvants in said base, (i) at least one of the following:
- a flavourant, colourant, perfuming agent, surface active ingredient, antiseptic or pharmaceutically active agent, and (ii) an ingredient capable of stimulating the cold receptors of the nervous system of the surface tissues of the body in those parts of the human body with which the product comes in contact during use, the improvement which comprises using as the cold receptor stimulating ingredient an effective amount of a substantially odourless cold receptor stimulating compound of the formula:
- ##STR2## wherein R' is hydrogen or an alkyl, cycloalkyl, alkenyl, cycloalkenyl, hydroxyalkyl, alkynyl, acyloxyalkyl, alkoxyalkyl, aminoalkyl, acylaminoalkyl, carboxyalkyl radical or an alkylcarboxyalkyl radical of the formula -- C.sub.n H.sub.2n COOR'", wherein -- C.sub.n H.sub.2n is a straight or branched chain alkylene group in which n is an interger from 1 to 6 and R'" is C.sub.1 -C.sub.8 alkyl, each of said radicals containing up to 25 carbon atoms;
- and R" is hydroxyl or an alkyl, cycloalkyl, alkenyl, cycloalkenyl, hydroxyalkyl, alkynyl, acyloxyalkyl, alkoxyalkyl, aminoalkyl, acylaminoalkyl, carboxyalkyl radical or an alkylcarboxyalkyl radical of the formula -- C.sub.n H.sub.2n COOR'", wherein -- C.sub.n H.sub.2n is a straight or branched chain alkylene group in which n is an integer from 1 to 6 and R'" is C.sub.1 -C.sub.8 alkyl, each of said radicals containing up to 25 carbon atoms;
- with the proviso that when R' is hydrogen R" may also be an aryl radical of up to 10 carbon atoms selected from benzyl and substituted phenyl wherein the substituents are selected from C.sub.1 -C.sub.4 alkyl, hydroxy, C.sub.1 -C.sub.4 alkoxy, nitro and halogen.
A product according to claim 7, which is a cosmetic preparation comprising an oil-in-water emulsion base, and, as adjuvants in said base, (i) at least one of the following:
- an antiseptic, perfuming agent or colourant and (ii) said cold receptor stimulant.
Dependencies are inferred from the claim text.