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US 4,132,753 AGranted
Process for preparing oral sustained release granules
AssigneeAmerican Cyanamid Company
InventorsMitchell S. Blichare, Gerald J. Jackson, Jr.
Life of this patent
Estimating the term…
Abstract
This disclosure relates to the process of preparing granules of controlled release medicament by continually agitating a mixture of powdered medicament and finely divided wax-like material while subjecting the mixture to radiation heating.
Claims16
A process of preparing granules of controlled release medicament which comprises:
- continuously agitating a mixture of (a) powdered medicament and (b) finely divided wax-like material having a melting point between about 30.degree. C and 100.degree. C, while subjecting the mixture to radiation heating at a temperature sufficiently high that the medicament powder has a temperature higher than the melting point of the wax-like material, the temperature of the medicament powder also being higher than the actual temperature of the wax-like material, whereby the hotter medicament powder sinks into the molten surfaces of the wax-like material to form granules comprising medicament powder and wax-like material;
- and cooling, lubricating, and sizing the resulting granules to sizes between about 12 and 60 mesh.
Dependencies are inferred from the claim text.