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US 4,131,611 AGranted
Azabicyclohexanes
AssigneeAmerican Cyanamid Company
InventorsWilliam J. Fanshawe, Joseph W. Epstein, Lantz S. Crawley, Corris M. Hofmann, Sidney R. Safir
Life of this patent
Estimating the term…
Abstract
Substituted 3-azabicyclo[3.1.0]hexanes, acid addition salts, method of use and method of preparation are described. The compounds have anxiolytic and analgesic activity.
Claims69
An optically active compound of the formula:
- ##STR46## wherein the phenyl moiety is unsubstituted or mono- or di-substituted from the group consisting of halogen, straight chain and mono-branched C.sub.1 -C.sub.6 alkyl, trifluoromethyl, and nitro;
- X is selected from the group consisting of hydrogen, straight chain C.sub.1 -C.sub.8 alkyl, and a moiety of the formula C.sub.n H.sub.2n R.sub.1, wherein n is an integer from 1 to 3 and R.sub.1 is phenyl;
- the racemic mixture thereof;
- the mirror image thereof;
- and the non-toxic pharmaceutically acceptable salts thereof.
2 more elements
The compound 3-[4,4-bis(p-Fluorophenyl)butyl]-1-phenyl-3-azabicyclo[3.1.0]hexane Fumarate.
The compound 3-[4,4-bis(p-Fluorophenyl)butyl]-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hex ane.
An optically active compound of the formula:
- ##STR47## wherein the phenyl moiety is mono- or di-substituted from the group consisting of phenyl, halophenyl and C.sub.3 -C.sub.6 cycloalkyl, X is selected from the group consisting of hydrogen, straight chain C.sub.1 -C.sub.8 alkyl, and a moiety of the formula C.sub.n H.sub.2n R.sub.1, wherein n is an integer from 1 to 3 and R.sub.1 is selected from the group consisting of halophenyl, and bis-halophenyl;
- the racemic mixture thereof;
- the mirror image thereof;
- and the non-toxic pharmaceutically acceptable salts thereof.
1 more element
An optically active compound of the formula:
- ##STR48## wherein the phenyl moiety is unsubstituted or mono- or di-substituted from the group consisting of halogen, straight chain C.sub.1 -C.sub.6 alkyl, trifluoromethyl, and nitro;
- X is selected from the group consisting of C.sub.3 -C.sub.6 cycloalkylmethyl, C.sub.3 -C.sub.6 alkenyl and C.sub.3 -C.sub.6 alkynyl;
- the racemic mixture thereof;
- the mirror image thereof;
- and the non-toxic pharmaceutically acceptable salts thereof.
2 more elements
An optically active compound of the formula:
- ##STR49## wherein the phenyl moiety is unsubstituted or mono- or di-substituted from the group consisting of halogen, straight chain C.sub.1 -C.sub.6 alkyl, trifluoromethyl, and nitro;
- X is selected from the group consisting of hydrogen, straight chain C.sub.1 -C.sub.8 alkyl, and a moiety of the formula C.sub.n H.sub.2n R.sub.1, wherein n is an integer from 1 to 3 and R.sub.1 is phenyl;
- R is selected from the group consisting of hydrogen and C.sub.1 -C.sub.3 alkyl;
- with the proviso that at least one R must be selected from the group consisting of C.sub.1 -C.sub.3 alkyl;
- the racemic mixture thereof;
- the mirror image thereof;
- and the non-toxic pharmaceutically acceptable salts thereof.
4 more elements
Dependencies are inferred from the claim text.