US 4,128,666 AGranted

4 AND 5-Halo substituted 2-indanamine compounds

AssigneeSmithKline Corporation

InventorsWilliam E. Bondinell, Robert G. Pendleton

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2-Indanamine compounds having 4 and 5-halo substituents are inhibitors of phenylethanolamine N-methyltransferase.

Dependent claims

A compound of the formula:

##STR8## in which:
R.sub.1 and R.sub.2 are chloro, bromo, fluoro, iodo or trifluoromethyl, R.sub.1 and R.sub.2 being the same or different or a pharmaceutically acceptable acid addition salt thereof.

Dependencies are inferred from the claim text.

C07D 303/08
Compounds containing oxirane rings: with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00
C07C 35/52
Halogenated derivatives: alcohols with a condensed ring system
C07C 45/45
Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds: by condensation

No related US applications are recorded in the indexed filing history.

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