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US 4,123,523 AGranted
Analgesic and sedative polypeptides
AssigneeImperial Chemical Industries PLC
InventorsAnand S. Dutta, James J. Gormley, Christopher F. Hayward, John S. Morley, Nigel N. Petter, Gilbert J. Stacey
Life of this patent
Estimating the term…
Abstract
The disclosure relates to novel polypeptides which possess analgesic and sedative activity, to processes for their manufacture and to compositions containing them. Typical of the peptides disclosed is H-Tyr-D-Ala-Gly-Phe-Leu-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-OH.
Claims10
A polypeptide of the formula:-
- H-Tyr-A-Gly-Phe-B-P-E I
- in which A is selected from the group consisting of D-Ala, D-Ser, D-Met and Gly;
- B is selected from the group consisting of Leu and Met, E is selected from the group consisting of a hydroxy and amino radical and an alkoxy radical of 1 to 6 carbons;
- and P is a peptide residue selected from those of the formula:-
- Lys-Lys II
- asn-Ala-Y-Lys-Lys III
- ala-Ile-X-Lys-Asn-Ala-Y-Lys-Lys IV
- thr-Leu-Phe-Lys-Asn-Ala-Ile-X-Lys-Asn-Ala-Y-Lys-Lys V
- and ##STR7## in which X is Val or Ile and Y is Tyr or His;
- and the pharmaceutically-acceptable acid-addition salts thereof, and where the polypeptide of the formula I contains a free carboxygroup, the pharmaceutically-acceptable base-addition salts thereof.
7 more elements
Dependencies are inferred from the claim text.