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US 4,123,465 AGranted
Chiral tertiary phosphines
AssigneeHoffmann-La Roche Inc.
InventorDonald H. Valentine, Jr.
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Abstract
A method for the homogeneous catalytic enantioselective hydrogenation of alkyl and alkenyl substituted acrylic acids wherein these acids are selectively hydrogenated at the double bond alpha,beta to the acid function, said hydrogenations are catalyzed by rhodium complexes of chiral tertiary phosphines. This method provides a route to chiral dihydrogeranic acid and other intermediates useful in the synthesis of chiral vitamin E, citronellal, and menthol. Novel chiral tertiary phosphines are also disclosed.
Claims10
A chiral phosphine of the formula:
- ##STR10## wherein R.sub.7 is methyl, isopropyl, xylyl, mesityl, benzyl, aryl or a substituted aryl selected from the group consisting of tolyl, ethylphenyl, cyclohexylphenyl, dimethylphenyl and methoxyphenyl;
- R.sub.8 is lower alkyl, aryl or a substituted aryl selected from the group consisting of tolyl, dimethylphenyl and methoxyphenyl;
- R.sub.9 is hydrogen, alkyl, hydroxylalkyl, aminoalkyl, perfluoroalkyl, aryl or methoxyphenyl;
- R.sub.10 is hydrogen, alkyl, aryl, hydroxyalkyl, aminoalkyl or perfluoroalkyl, with the proviso that R.sub.9 and R.sub.10 must be different;
- R.sub.11 is hydrogen, alkyl or aryl.
2 more elements
Dependencies are inferred from the claim text.