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US 4,118,417 AGranted
Process for resolving cis-1-substituted phenyl-1,2-cyclopropanedicarboxylic acids
AssigneeAmerican Cyanamid Company
InventorJoseph William Epstein
Life of this patent
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Abstract
A method for resolving racemic substituted cyclopropanedicarboxylic acids which are useful as intermediates for the preparation of substituted phenyl azabicyclohexanes which possess anxyolitic and analgesic activity.
Claims3
A method for resolving a compound of the formula:
- ##STR3## wherein R is selected from the group consisting of hydrogen and C.sub.1 -C.sub.6 alkyl;
- and the phenyl moiety is unsubstituted, mono- or di-substituted from the group consisting of hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, trifluoromethyl, nitro, amino, acetamido and hydroxy;
- into their (+) and (-) isomers which comprises reacting said compound with either (+) or (-)-.alpha.-(1-naphthyl)-ethylamine, in tetrahydrofuran, to produce a solid;
- collecting said solid, slurring in water, basifying, extracting with ether, and acidifying.
1 more element
Dependencies are inferred from the claim text.