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US 4,117,118 AGranted
Organic compounds
AssigneeSandoz Ltd.
InventorsEugen Harri, Artur Ruegger
Life of this patent
Estimating the term…
Abstract
This invention provides new antibiotics produced by cultivating a strain of the fungus species, Cylindrocarpon lucidum Booth or Tolypocladium inflatum Gams in contact with a nutrient medium, the antibiotics being useful anti-inflammatory and immunosuppressive agents.
Claims16
Antibiotic S7481/F-1 having the following characteristics, when an amorphous form:
- U.v. spectrum [CH.sub.3 OH;
- c = 1.063 g/1;
- d = 0.01 cm] as shown in FIG. 1 of the accompanying drawings,
- I.r. spectrum [CH.sub.2 Cl.sub.2 ] as shown in FIG. 2 of the accompanying drawings,
- Proton N.M.R. spectrum [90 MHz;
- CDCL.sub.3 ] as shown in FIG. 3 of the accompanying drawings,
- High resolution mass spectrum [ion acceleration 4kv;
- temperature ion source 290.degree. C;
- pressure 5.10.sup.-6 mm Hg] peak of mass = m/e 1183.831 [.+-. 0.004] corresponding to C.sub.62 H.sub.109 N.sub.11 O.sub.11 recognisable as product of elimination of water from C.sub.62 H.sub.111 N.sub.11 O.sub.12 ;
- and empirical formula C.sub.62 H.sub.111 N.sub.11 O.sub.12 ;
- or antibiotic S7481/F-2 having the following characteristics, when in amorphous form:
- U.v. spectrum [CH.sub.3 OH;
- c = 1.062 g/l;
- d = 0.01 cm] as shown in FIG. 4 of the accompanying drawings;
- I.r. spectrum [CH.sub.2 Cl.sub.2 ] as hown in FIG. 5 of the accompanying drawings;
- Proton N.M.R. spectrum [90 MHz;
- CDCl.sub.3 ] as shown in FIG. 6 of the accompanying drawings;
- High resolution mass spectrum [ion acceleration 4 kv;
- ion source temperature 290.degree. C;
- pressure 5.10.sup.-6 mm Hg] peak of mass m/e 1169.815 (.+-. 0.006) corresponding to C.sub.61 H.sub.107 N.sub.11 O.sub.11, the product of water elimination from C.sub.61 H.sub.109 N.sub.11 O.sub.12 ;
- empirical formula C.sub.61 H.sub.109 N.sub.11 O.sub.12.
18 more elements
S7481/F-1 of structure ##STR3##
S7481/F-2 of structure ##STR4##
Dependencies are inferred from the claim text.