Binuclear phenols for reducing plasma lipid levels
AssigneeEthyl Corporation
InventorSidney I. Lerner
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Abstract
Plasma lipid levels are reduced by internally administering to a mammal a binuclear phenol. The two aromatic rings may be bonded together directly as in 4,4'-bis(2,6-di-tert-butylphenol). Likewise, the aromatic rings may be bonded through a bridging group such as --CH.sub.2 --CH.sub.2 --, --SO--, --S.sub.m --, --O--CH.sub.2 --CH.sub.2 --O--, --CH.sub.2 --SO.sub.2 --, --CH.sub.2 --S.sub.n --CH.sub.2 --, --CH.sub.2 --O--CH.sub.2 --, and ##STR1##
Claims16
A method of treating a mammal whose abnormally high plasma lipid level is to be reduced which comprises internally administering 4,4'-ethylenebis(2,6-di-tert-butylphenol) in an amount sufficient to reduce said plasma lipid level.
A method of treating a mammal whose abnormally high plasma lipid level is to be reduced which comprises internally administering 4,4'-thiobis(6-tert-butyl-o-cresol) in an amount sufficient to reduce said plasma lipid level.
A method of treating a mammal whose abnormally high plasma lipid level is to be reduced which comprises internally administering a bisphenol having the formula:
- ##STR7## wherein:
- R is selected from the group consisting of alkyl having from 1-20 carbon atoms, cycloalkyl having from 6-12 carbon atoms, aryl having from 6-12 carbon atoms, and aralkyl having from 7-12 carbon atoms, a and b are each independently selected from 0-4;
- x is selected from 0 and 1;
- and A is selected from the group consisting of --SO--, --S.sub.m --, --O--CH.sub.2 --CH.sub.2 --O--, --CH.sub.2 SO.sub.2, CH.sub.2 --S.sub.n --CH.sub.2 and CH.sub.2 --O--CH.sub.2 and ##STR8## wherein m is from 1-4, nis from 0-4 and R.sub.1 is selected from the group consisting of hydrogen and R;
- in an amont sufficient to reduce said plasma lipid level.
A method for lowering serum cholesterol in animals comprising administering orally to an animal having high serum cholesterol level the compound 2,2',6,6'-tetra-tert-butyl-p,p'-biphenol in a hypocholesteremic amount sufficient to provide a reduction in serum cholesterol content.
A method for lowering serum cholesterol in animals comprising administering orally to an animal a member selected from the group consisting of 4,4'-bis(2,6-di-tert-butylphenol and 2,2'-di-tert-butyl-6,6'-diisopropyl-p,p'-biphenol in an amount of from 0.8 to 1000 milligrams of compound per kilogram of animal body weight per day.
A method for lowering serum cholesterol in an animal comprising administering orally to an animal a compound selected from the group consisting of 4,4'-thiobis(6-tert-butyl-m-cresol), 4,4'-thiobis(6-tert-butyl-o-cresol), and .alpha.,.alpha.'-thiobis(2,6-di-tert-butyl-p-cresol) in a daily dosage of from about 0.8 to about 1,000 milligrams of compound per kilogram of animal body weight.
A method for lowering serum cholesterol levels in animals comprising administering orally to an animal having a high serum cholesterol level an amount of a thiobis cresol compound effective to lower the serum cholesterol level in said animal, said thiobis cresol compound being a compound selected from the group consisting of 4,4'-thiobis(6-tert-butyl-m-cresol), 4,4'-thiobis(6-tert-butyl-o-cresol) and .alpha.,.alpha.'-thiobis (2,6-di-tert-butyl-p-cresol).
Dependencies are inferred from the claim text.