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US 4,115,564 AGranted
Treatment of diarrhea with amidinoureas
AssigneeWilliam H. Rorer, Inc.
InventorsJulius Diamond, George H. Douglas
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Abstract
A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-diarrheal agents.
Claims12
A method for the treatment of diarrhea in humans and mammals which comprises the administering thereto between 0.01 to 500 mg/kg per day of a compound of the formula:
- ##STR13## where:
- R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 may be the same or different and are:
- hydrogen, halo, loweralkyl, haloloweralkyl, nitro, loweralkoxy, hydroxy, arloweralkoxy, acyloxy, cyano, haloloweralkoxy or loweralkylsulfonyl;
- R and R.sub.n are hydrogen or loweralkyl;
- and
- R' and R" together form a ring containing a group selected from the group consisting of tetramethylene, pentamethylene and hexamethylene 5- 7 atom ring which may additionally include 0- 2 hetero atoms of N,O or S;
- and the non-toxic acid addition salts thereof.
4 more elements
Dependencies are inferred from the claim text.