US 4,115,313 AGranted

Bile acid emulsions

OwnerIrving Lyon, Harriette Lyoninventors

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Abstract

The invention is directed to emulsion compositions of, or including, bile acids, their conjugates, lower alcohol esters or salts of said acids or conjugates; water to effect solution of one or more of said defined bile acids; and at least one of: glycerides; phospholipids; fatty acids, amino fatty acids, or fatty acid amides; and steroids. Illustrative are sodium taurocholate, glyceryl monooleate, soy lecithin, oleic acid and cholesterol acetate. The emulsion compositions in conjunction with oil and/or water phase(s) can be controlled to give an emulsion product which is substantially stable water/oil type or oil/water type, or metastable mixture of water/oil and oil/water types. The emulsion product has utility in many fields such as cosmetics, dentifrices, food products, cleaners, lubricants, agricultural chemicals, etc; The emulsion composition itself has utility in many of these fields.

Claims9

Dependent claims

An emulsion composition consisting essentially of:

(1) bile acid member selected from the class consisting of bile acids, bile acid conjugates, lower alcohol esters of bile acids or bile acid conjugates, salts of bile acids or bile acid conjugates, and mixtures thereof;
(2) water to effect solution of said bile acid member;
and
(3) at least one component selected from the class consisting of:
(a) glycerides of fatty acids having about 12-22 carbon atoms;
(b) phospholipids selected from the group consisting of (i) glycerol esters containing alpha or beta phosphoric acid and (ii) a hydroxy-containing compound combined in an ester link with a phosphate group;
(c) fatty acids, amino fatty acids, or fatty acid amides, where said fatty acids have about 12-22 carbon atoms and said amino fatty acids and said fatty acid amides are derivable from fatty acids having about 12-22 carbon atoms;
and
(d) steroids selected from the group consisting of (i) animal sterols and (ii) vegetable sterols, where said bile acid member and each of said (a), (b), (c) and (d) units of said component (3), when present, is present in said emulsion composition in an amount between about 10 and 250 millimoles per liter of said bile acid member-water solution, and where the molar proportion of each of said components 3a, 3b, 3c and 3d, when present, lies in the range of about 0.3-3 moles per mole of said component (1) present.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application: 05/657,225Filed 11 Feb 1976 · continuation in part
Priority: 8 Oct 1974
Granted: 19 Sep 1978
Term ends: Not estimatedThe source records don’t support an estimate.

Classification38 codes

A61K 8/361
Carboxylic acids; Salts or anhydrides thereof: carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
A21D 2/08
Treatment of flour or dough by adding materials thereto before or during baking: by adding organic substances
A23L 13/42
Containing additives: additives other than enzymes or microorganisms in meat products or meat meals
A23L 27/00
Spices