2-Decarboxy-2-hydroxymethyl-.omega.-phenoxy-PGD analogs
AssigneeThe Upjohn Company
InventorNorman A. Nelson
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Abstract
This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
Claims83
A prostaglandin analog of the formula ##STR1## WHEREIN R.sub.8 is hydrogen or hydroxy;
- WHEREIN Y is trans-CH.dbd.CH--;
- wherein M.sub.1 is ##STR2## wherein R.sub.5 is hydrogen or hydroxy;
- WHEREIN L.sub.1 is ##STR3## or a mixture of ##STR4## wherein R.sub.3 and R.sub.4 are hydrogen or methyl, being the same or different;
- Wherein Z.sub.2 is
- Cis-CH.dbd.CH--CH.sub.2 --(CH.sub.2).sub.g --CF.sub.2 --;
- cis-CH.sub.2 --CH.dbd.CH--(CH.sub.2).sub.g --CH.sub.2 --;
- or
- --(CH.sub.2).sub.3 --(CH.sub.2).sub.g --CF.sub.2 --;
- wherein g is one, 2, or 3;
- and
- Wherein s is zero, one, 2, or 3 and T is chloro, fluoro, trifluoromethyl, alkyl of one to 3 carbon atoms, inclusive, or alkoxy of one to 3 carbon atoms, inclusive, the various T's being the same or different, with the proviso that not more than two T's are other than alkyl.
Dependencies are inferred from the claim text.