Process for the production of clavulanic acid
AssigneeBeecham Group Limited
InventorsMartin Cole, Thomas T. Howarth, Christopher Reading
Life of this patent
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Abstract
A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria.
Claims19
A process for the production of clavulanic acid or a salt thereof which comprises cultivating a strain of Streptomyces clavuligerus in a suitable medium containing assimilable sources of carbon, nitrogen and mineral salt and isolating the clavulanic acid or salt thereof from the culture medium.
Dependencies are inferred from the claim text.