Imidazolylmethyl methanobenzazocines

Abstract

1,2,3,4,5,6-Hexahydro-3-(Y)-6-(R.sup.1)-11-(R.sup.2)-2,6-methano-3-benzazoc ines, wherein Y is cycloalkyl-lower alkyl, lower alkyl-cycloalkyl-lower alkyl, carboxy-lower alkyl, cyano-lower alkyl, carbamyl-lower alkyl, tetrahydrofurylmethyl, 2-(2- or 3-indolyl)ethyl, amino-lower alkyl, butylcarbamyl, pyridinecarbonyl, (1-lower alkyl-imidazol-5-yl)methyl, 2,2-dimethoxyethyl, lower alkenyl, halo-lower alkenyl or cyano-lower alkenyl, R.sup.1 is lower alkyl and R.sup.2 is hydrogen or lower alkyl, are obtained starting with the corresponding 3-(H) compounds, in some instances via 3-acylated intermediate amides. The products have useful central depressant and psychomotor action, the preferred species wherein Y is cycloalkyl-lower alkyl or lower alkylcycloalkyl-lower alkyl being useful as analgesic agents in humans.

Dependencies are inferred from the claim text.