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US 4,107,288 AGranted
Injectable compositions, nanoparticles useful therein, and process of manufacturing same
AssigneePharmaceutical Society of Victoria
InventorsRichard Charles Oppenheim, Jennifer Joy Marty, Peter Speiser
Life of this patent
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Abstract
Particles in the size range from about 10 to about 1000 nm, preferably less than about 500 nm, which comprise a crosslinked matrix of macromolecules of natural origin. A biologically or pharmacodynamically active material may be supported on or incorporated into the matrix.
Claims18
A process of manufacturing particles in the size range from about 10 to about 1000 nanometres which particles comprise a crosslinked matrix of macromolecules of natural origin, which method consists essentially of:
- (a) solvating the macromolecules to form a thermally equilibrated clear solution;
- (b) treating said solution with a desolvating agent until the macromolecules have reached the desolvation region which is the region at which the intensity of scattered light is markedly increased, but before the point at which the solution becomes turbid;
- and,
- (c) adding an aldehyde hardening agent to the mixture.
1 more element
Dependencies are inferred from the claim text.