Proline derivatives and related compounds

A compound of the formula ##STR41## wherein R is hydroxy or lower alkoxy;

• R.sub.1 is hydrogen or lower alkyl;
• R.sub.2 is hydrogen or lower alkanoyl;
• n is 0, 1 or 2;
• and
• physiologically acceptable salts thereof, said lower alkoxy, lower alkyl and lower alkanoyl groups having up to seven carbon atoms.

A compound of the formula ##STR43## wherein R is hydroxy or lower alkoxy;

• R.sub.1 and R.sub.4 each is hydrogen, lower alkyl, phenyl or phenyl-lower alkyl;
• R.sub.2 is hydrogen, lower alkyl, phenyl, substituted phenyl wherein the phenyl substituent is halo, lower alkyl or lower alkoxy, phenyl-lower alkyl, diphenyl-lower alkyl, triphenyl-lower alkyl, lower alkylthiomethyl, phenyl-lower alkylthiomethyl, lower alkanoylamidomethyl, ##STR44## R.sub.6 -S- or R.sub.7 ;
• R.sub.3 is hydrogen, hydroxy or lower alkyl;
• R.sub.5 is lower alkyl, phenyl or phenyl-lower alkyl;
• R.sub.6 is lower alkyl, phenyl, substituted phenyl, wherein the phenyl substituent is halo, lower alkyl or lower alkoxy, hydroxy-lower alkyl or amino(carboxy)lower alkyl;
• ##STR45## M is 0 or S;
• m is 2;
• n and p each is 0, 1 or 2;
• and physiologically acceptable salts thereof, said lower alkoxy, lower alkyl and lower alkanoyl groups having up to seven carbon atoms.