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US 4,105,681 AGranted
9-Phenyl 5,6-dimethyl-nona-2,4,6,8-tetraeonic acid compounds
AssigneeHoffmann-La Roche Inc.
InventorsWerner Bollag, Rudolf Ruegg, Gottlieb Ryser
Life of this patent
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Abstract
Novel 9-phenyl 5,6-dimethyl-nona-2,4,6,8-tetraenoic acid,-tetraenal or tetraenol derivatives useful as anti-tumor agents.
Claims18
A compound of the formula ##STR16## wherein R.sub.1 and R.sub.2 are lower alkyl;
- R.sub.3 is hydrogen, lower alkyl, lower alkoxy, lower alkenyloxy, nitro, halo, amino, lower alkylamino, lower alkanoylamino R.sub.4 is hydrogen, lower alkyl, lower alkenyl, lower alkoxy, lower alkenyloxy, nitro, lower alkanoyloxy, amino, lower alkylamino R.sub.5 is hydrogen, lower alkyl, lower alkenyl, lower alkoxy, lower alkenyloxy, nitro, halo, amino, lower alkanoylamino, lower alkylamino with the proviso that at least one of R.sub.3, R.sub.4 and R.sub.5 is other than hydrogen;
- with the further proviso that when R.sub.3 or R.sub.5 is halogen, R.sub.4 is other than alkoxy;
- and R.sub.6 is carboxyl and pharmaceutically acceptable salts thereof.
The compound of claim 63 wherein said compound is 9-(4-methoxy-3-allyl-2,6-dimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetrae n-1-oic acid.
Dependencies are inferred from the claim text.