US 4,104,371 A · Psychopharmacologically active peptides and peptide-derivatives, and the use thereof

Abstract

Biologically active novel peptides and peptide-derivatives of the general formula: ##STR1## where A represents H-(L or D)Met, H-(L or D)Met(.fwdarw.O), H-(L or D)Met(.fwdarw.O.sub.2) desamino-Met, desamino-Met(.fwdarw.O), desamino-Met(.fwdarw.O.sub.2) or the group H.sub.2 N--B--CO--; B represents a branched or straight-chain alkylene (C.sub.1 -C.sub.6) or alkylidene (C.sub.1 -C.sub.6) group; Q represents the amino-acid residue --NH--CHR--CO--; R represents alkyl (C.sub.1 -C.sub.6), p-hydroxyphenylmethyl, 3-indolylmethyl or phenylmethyl; R.sub.1 and R.sub.2 represent hydrogen or an alkyl(1-6C) group, and Z represents N-(phenylalkyl)amino, N-(.beta.-indolylalkyl)amino, L-Trp-OH, L-Phe-OH, L-Trp-Gly-OH or L-Phe-Gly-OH, as well as the functional derivatives thereof.

Claims23

Dependent claims

Compound of the formula:

##STR4## and their functional derivatives, wherein:
A is an N-terminal chain prolongation selected from the group consisting of H-(L or D)Met, H-(L or D) Met(.fwdarw.O), H-(L or D)Met(.fwdarw.O.sub.2), desamino-Met, desaminoMet(.fwdarw.O), desamino-Met(.fwdarw.O.sub.2), and H N-B-CO-, wherein B represents a branched or straight-chain alkylene (C.sub.1 -C.sub.6) or alkylidene (C.sub.1 -C.sub.6) group;
Q is an amino-acid residue -NH-CHR-CO-, wherein R is selected from the group consisting of alkyl (C.sub.1 -C.sub.6), p-hydroxyphenylmethyl, 3-indolymethyl, and phenylemethyl radicals;
R.sub.1 and R.sub.2 each selected from hydrogen and alkyl (1-6C) groups;
and
Z is selected from the group consisting of N-(phenylalkyl)amino, N-(B-indolylalkyl)amino, L-Trp, L-Phe-OH, L-Trp-Gly-OH, and L-Phe-Gly-OH.

3 more elements

Dependencies are inferred from the claim text.

Psychopharmacologically active peptides and peptide-derivatives, and the use thereof

Life of this patent

Psychopharmacologically active peptides and peptide-derivatives, and the use thereof

Life of this patent

Abstract

Claims23