1,2,3-Thiadiazole amides
AssigneeBristol-Myers Company
InventorsRonnie R. Crenshaw, Richard A. Partyka
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Abstract
A series of novel 4-amino-2-(thiadiazole-carbonyl piperazinyl)-6,7-dimethoxyquinazolines is disclosed having antihypertensive properties. The thiadiazole substituent may be optionally substituted with alkyl or lower alkoxy carbonylamino groups. A representative embodiment of the invention is 4-amino-6,7-dimethoxy-2-[4-(5-ethoxy-carbonylamino-1,2,3-thiadiazole-4-car bonyl)-piperazin-1-yl]-quinazoline.
Claims6
A compound having the formula ##STR26## or a pharmaceutically acceptable salt thereof wherein R.sub.1 is hydrogen, amino, lower alkyl of 1 to 4 carbon atoms inclusive or NHCO.sub.2 R.sub.2 in which R.sub.2 is lower alkyl of 1 to 4 carbon atoms inclusive.
Dependencies are inferred from the claim text.