(1-Oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio) alkanoic acids, and derivatives thereof

A compound of the formula:

• ##STR21## wherein R.sup.0 is ##STR22## R is lower alkyl;
• X.sup.1 and X.sup.2 are selected from the group consisting of chloro and methyl;
• X.sup.3 is hydrogen, nitro, hydroxy, lower alkyl, lower alkoxy, cycloalkyl, halo, amino, cyano, sulfamoyl, methanesulfonyl, chlorosulfonyl or aminomethyl;
• and the non-toxic, pharmacologically acceptable salt derivatives thereof.

A pharmaceutical composition useful in the treatment of edema and hypertension which also maintains uric acid at pretreatment levels or causes a decrease in uric acid levels which comprises a therapeutically effective amount of a compound of the formula:

• ##STR29## wherein R.sup.0 is ##STR30## A is oxygen or sulphur;
• R is lower alkyl, lower alkenyl, phenyl lower alkyl, phenyl lower alkenyl, phenyl, cycloalkyl, or cycloalkyl lower alkyl;
• R is hydrogen, lower alkyl, or phenyl;
• or
• R.sup.1 and R may be joined together to form a cycloalkylene;
• Y is alkylene or haloalkylene containing from 1 to about 4 carbon atoms;
• X.sup.3 is hydrogen, nitro, hydroxy, lower alkyl, lower alkoxy, cycloalkyl, halo, amino, cyano, sulfamoyl, methanesulfonyl, chlorosulfonyl, aminomethyl, acylamino or acylaminomethyl;
• X.sup.1 is hydrogen, halo or methyl;
• X.sup.2 is halo, methyl or trihalomethyl;
• or
• X.sup.1 and X.sup.2 may be joined together to form a hydrocarbylene chain containing from 3 to about 4 carbon atoms;
• and the non-toxic, pharmacologically acceptable salt, amide, anhydride, and ester derivatives thereof, and a pharmaceutically acceptable carrier.

A pharmaceutical composition useful in the treatment of edema and hypertension which also maintains uric acid at pretreatment levels or causes a decrease which comprises from about 1 mg. to about 500 mg. of a compound of the formula:

• ##STR31## wherein R.sup.0 is ##STR32## R is lower alkyl;
• X.sup.1 and X.sup.2 are selected from the group consisting of chloro and methyl;
• X.sup.3 is hydrogen, nitro, hydroxy, lower alkyl, lower alkoxy, cycloalkyl, halo, amino, cyano, sulfamoyl, methanesulfonyl, chlorosulfonyl, aminomethyl, acylamino or acylaminomethyl;
• a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

A method for the treatment of edema, hyperuricemia, and hypertension which comprises administering in a therapeutically effective unitary dosage form a compound of the formula:

• ##STR34## wherein R.sup.0 is ##STR35## A is oxygen or sulphur;
• R is lower alkyl, lower alkenyl, phenyl lower alkyl, phenyl lower alkenyl, phenyl, cycloalkyl or cycloalkyl lower alkyl;
• R.sup.1 is hydrogen, lower alkyl or phenyl;
• or
• R.sup.1 and R may be joined together to form a cycloalkylene;
• Y is alkylene or haloalkylene containing from 1 to about 4 carbon atoms;
• X.sup.3 is hydrogen, nitro, hydroxy, lower alkyl, lower alkoxy, cycloalkyl, halo, amino, cyano, sulfamoyl, methanesulfonyl, chlorosulfonyl, aminomethyl, acylamino or acylaminomethyl;
• X.sup.1 is hydrogen, halo or methyl;
• X.sup.2 is halo, methyl or trihalomethyl;
• or
• X.sup.1 and X.sup.2 may be joined together to form an hydrocarbylene chain containing from 3 to about 4 carbon atoms;
• and the non-toxic, pharmacologically acceptable salt, amide, anhydride and ester derivatives thereof.

A pharmaceutical composition useful in the treatment of edema and hypertension which also maintains uric acid levels at pretreatment levels or causes a decrease in uric acid levels which comprises a therapeutically effective amount of a compound of the formula:

• ##STR39## wherein R.sup.0 is ##STR40## A is oxygen or sulphur;
• R is lower alkyl, lower alkenyl, phenyl lower alkyl, phenyl lower alkenyl, phenyl, cycloalkyl or cycloalkyl lower alkyl;
• R.sup.1 is hydrogen, lower alkyl or phenyl;
• or
• R.sup.1 and R may be joined together to form a cycloalkylene;
• Y is alkylene or haloalkylene containing from 1 to about 5 carbon atoms;
• X.sup.3 is hydrogen, nitro, hydroxy, lower alkyl, lower alkoxy, cycloalkyl, halo, amino, cyano, sulfamoyl, methanesulfonyl, chlorosulfonyl or aminomethyl;
• X.sup.1 is hydrogen, halo or methyl;
• X.sup.2 is halo, methyl or trihalomethyl;
• or
• X.sup.1 and X.sup.2 may be joined together to form a hydrocarbylene chain containing from 3 to about 4 carbon atoms;
• and the non-toxic, pharmacologically acceptable salt, amide, anhydride and ester derivatives thereof and an effective antihypertensive agent along with a pharmaceutically acceptable carrier.

A pharmaceutical composition useful in the treatment of edema and hypertension which also maintains uric acid levels at pretreatment levels or causes a decrease in uric acid levels which comprises a therapeutically effective amount of two or more compounds of the formula:

• ##STR41## wherein R.sup.0 is ##STR42## A is oxygen or sulphur;
• R is lower alkyl, lower alkenyl, phenyl lower alkyl, phenyl lower alkenyl, phenyl cycloalkyl or cycloalkyl lower alkyl;
• R.sup.1 is hydrogen, lower alkyl or phenyl;
• or
• R.sup.1 and R may be joined together to form a cycloalkylene;
• Y is alkylene or haloalkylene containing from 1 to about 4 carbon atoms;
• X.sup.3 is hydrogen, nitro, hydroxy, lower alkyl, lower alkoxy, cycloalkyl, halo, amino, cyano, sulfamoyl, methanesulfonyl, chlorosulfonyl or aminomethyl;
• X.sup.1 is hydrogen, halo or methyl;
• X.sup.2 is halo, methyl or trihalomethyl;
• or X.sup.1 and X.sup.2 may be joined together to form a hydrocarbylene chain containing from 3 to about 4 carbon atoms;
• and the non-toxic, pharmacologically acceptable salt, amide, anhydride and ester derivatives thereof along with a pharmaceutical carrier with the proviso that no two compounds can be exactly the same.

A compound of the formula ##STR43## wherein R.sup.2 is lower alkyl from 1 to 3 carbon atoms;

• X.sup.4 is methyl or chloro;
• X.sup.5 is methyl or chloro;
• X.sup.6 is hydrogen, methyl, chloro or fluoro;
• and the non-toxic pharmaceutically acceptable salts thereof.