Immunological adjuvant agents active in aqueous solution
AssigneeAgence Nationale de Valorisation de la Recherche
InventorsLouis A. Chedid, Francoise Marguerite Audibert
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Abstract
Immunological adjuvants obtainable from already-known water-soluble adjuvants containing peptidoglycane fragments, which include saccharide units formed from N-acetylglucosamine and from an N-acyl-muramic acid wherein the acyl group is a glycolyl or acetyl group and to the muramyl group there are attached peptide chains, by modification of said already-known water-soluble adjuvants so that they bear acylating groups derived from physiologically-acceptable carboxylic polyacids, especially carboxylic diacids, and wherein preferably the acylating groups themselves include free carboxylic acid groups, for instance being derived from phthalic acid or succinic acid.
Claims40
A compound, a water-soluble adjuvant which has immunological activity in-vivo when administered to a host in an oil-free aqueous solution, which adjuvant is an acylated peptidoglycane fragment having saccharide units of N-acetylglucosamine and N-acylmuramyl, the acyl radical being glycolyl or acetyl, and the muramyl group having peptide chains linked thereto,
- wherein the acyl groups of the peptidoglycane are of a physiologically acceptable polycarboxylic acid, or its anhydride, and the physiologically acceptable salts of the acylated compound.
An immunological adjuvant which is a water-soluble compound which is a saccharide having N-acetyl-glucosamine group and an N-acetyl muramic acid group, wherein the acyl is glycolyl or acetyl and having a peptide chain linked to the muramyl radical, which compound is acylated, the cylating radical being selected from the group consisting of phthalyl or succinyl thereof, in an isotonic, sterile, injectable aqueous medium.
A modified, water-soluble immunological adjuvant which is formed of break down fragments of cell-wall peptidoglycans containing saccharide units formed from N-acetyl glucosaminyl and N-acetylmuramyl groups, wherein the acyl groups is glycolyl or acetyl, and a peptide is linked to the muramyl group, which water-soluble immunological adjuvant carries modification-acylation groups fixed thereon and derived from physiologically-acceptable polycarboxylic acids of the type and in a proportion such as to enable said peptidoglycane break-down fragments to exert their adjuvant immunological activity in vivo when administered in the form of an oil-free, aqueous saline solution.
Dependencies are inferred from the claim text.