Water-dispersible protein/polyurethane reaction product
AssigneeW. R. Grace & Co.
InventorsFrank Joseph Hartdegen, Wayne Elliott Swann
Life of this patent
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Abstract
An aqueous dispersion of a biologically-active protein bound to polyurethane is formed by (a) admixing the protein and an isocyanate-capped liquid polyurethane prepolymer to form a solution; and (b) dispersing the solution in water.
Claims19
A method for preparing an aqueous solution of protein bound to a urethane polymer comprising:
- a. admixing a water-dispersible, biologically-active protein and an isocyanate-capped liquid polyurethane prepolymer having an oxyalkylene backbone containing at least 50 mole % of oxyethylene units under essentially anhydrous conditions to form a solution, said protein and prepolymer reacting to form a water-soluble reaction product wherein the protein and prepolymer are bound together;
- and
- b. dispersing the solution in water with agitation to form an aqueous solution of urethane-polymer bound protein.
An aqueous solution of a water-dispersible, biologically-active protein bound to a polyurethane characterized as having an essentially linear polyoxyalkylene backbone containing at least 50 mole % of oxyethylene units, said protein bound to said polyurethane through a ureido linkage, said polyurethane-bound protein being water-soluble.
An aqueous solution of a water-dispersible, biologically-active protein bound to a polyurethane, said bound protein formed by dissolving the protein in an isocyanate-capped liquid polyurethane prepolymer under essentially anhydrous conditions to form a solution, said protein and prepolymer reacting to form a water-soluble reaction product wherein the protein and prepolymer are bound together;
- said prepolymer having an essentially linear oxyalkylene backbone containing at least 50 mole % oxyethylene units;
- and dispersing the solution in water with agitation to form a solution of polyurethane bound protein.
An aqueous solution of a water-dispersible, biologically-active protein bound to a polyurethane characterized as having an essentially linear polyester backbone, said protein bound to said polyurethane through a ureido linkage, said polyurethane-bound protein being water-soluble.
A method for preparing an aqueous solution of protein bound to a urethane polymer comprising:
- a. admixing a water-dispersible, biologically-active protein and an isocyanate-capped liquid polyurethane prepolymer having a linear polyester backbone under essentially anhydrous conditions to form a solution, said protein and prepolymer reacting to form a water-soluble reaction product wherein the protein and prepolymer are bound together;
- and
- b. dispersing the solution in water with agitation to form an aqueous solution of urethane-polymer bound protein.
A method for preparing an aqueous dispersion of enzyme bound to a urethane polymer comprising:
- a. dispersing an enzyme in an isocyanate-capped liquid polyurethane prepolymer under essentially anhydrous conditions to form a solution;
- b. forming a dispersion by slowly adding said enzyme/polyurethane composition to water while agitating, and continuing agitation following addition of said composition;
- and
- c. separating insoluble bound enzymes from the aqueous dispersion.
A method for preparing an aqueous solution of protein bound to a urethane polymer comprising:
- a. dispersing of biologically-active protein in an isocyanate-capped liquid polyurethane prepolymer under essentially anhydrous conditions to form a solution;
- and
- b. dispersing the solution in water with agitation to form a solution of urethane polymer-bound protein.
Dependencies are inferred from the claim text.