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US 4,092,356 AGranted
11,12-Secoprostaglandins
AssigneeMerck & Co., Inc.
InventorsEdward J. Cragoe, Jr., John B. Bicking, Robert L. Smith
Life of this patent
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Abstract
This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of hypertension, for the prevention of thrombus formation, in preventing gastric secretion, and as regulators of the immune response.
Claims18
The compound having the following formula:
- ##STR51## wherein R is carboxy, a carboxy salt, or derivatized carboxy having the formula --COOY wherein Y is alkyl having 1-10 carbon atoms, 1-succinimidoethyl, 1-(pivaloyloxy)ethyl, 2-acetamidoethyl, or diloweralkylamino-loweralkyl;
- A is oxymethylene;
- R.sup.1 is formyl, acetyl, propionyl, acryloyl, hydroxyacetyl, 3-hydroxypropionyl, hydroxymethyl, 1-hydroxyethyl, 1,2-dihydroxyethyl, 1,3-dihydroxypropyl, or 1-hydroxy-1-methylethyl;
- Z is methylene, ethylene, trimethylene, tetramethylene, vinylene, or ethynylene;
- R.sup.2 is independently hydrogen or methyl;
- R.sup.3 is hydrogen;
- R.sup.4 is selected independently from the group consisting of hydrogen and methyl;
- and
- R.sup.5 is selected from the group consisting of hydrogen, lower alkyl of 1-4 carbon atoms either straight or branched (e.g., methyl, ethyl, propyl, isopropyl, butyl, tert-butyl), vinyl, and 2,2,2-trifluoroethyl.
6 more elements
Dependencies are inferred from the claim text.