Potentiated anesthetics
AssigneeJohnson & Johnson
InventorTibor Sipos
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Abstract
Topical anesthetic compositions are provided wherein there is obtained an enhancement of the activity of the topical anesthetic agent by combining the anesthetic agent with an effective amount of a penetrant accelerator selected from the group consisting of the cyclohexyl substituted alkanols of the structure ##STR1## wherein R.sub.1 is C.sub.1 to C.sub.4 alkyl, halogen or hydrogen; R.sub.2 and R.sub.3 are independently selected from hydrogen, C.sub.1 to C.sub.3 alkyl, and cyclopropyl; and n is 1 to 4, provided that only one of R.sub.2 and R.sub.3 may be propyl or cyclopropyl. The topical anesthetic compositions of the invention are applied to the skin of an animal in order to induce anesthesia topically in the animal.
Claims25
A topical anesthetic composition comprising an effective amount of a topical anesthetic agent and an amount of a penetrant accelerator effective to enhance the skin penetration of said anesthetic agent, said penetrant accelerator being selected from the group consisting of the cyclohexyl substituted alkanols of the structure ##STR11## wherein R.sub.1 is C.sub.1 to C.sub.4 alkyl, halogen or hydrogen;
- R.sub.2 and R.sub.3 are independently selected from hydrogen, C.sub.1 to C.sub.3 alkyl, and cyclopropyl;
- and n is 1 to 4, provided that only one of said R.sub.2 and R.sub.3 may be propyl or cyclopropyl.
In the topical inducement of anesthesia by applying to the skin of an animal a topical anesthetic agent, the improvement comprising potentiating the activity or penetration of the anesthetic agent by applying the same in conjunction with a potentiator which is a primary, secondary or tertiary cyclohexylalkanol or alkylcyclohexyl alkanol selected from the group consisting of cyclohexylmethanol, 1-cyclohexylethanol, 2-cyclohexylethanol, 1-cyclohexyl-1-propanol, (cyclohexyl)-dimethylcarbinol, (4,isoproyl-cyclohexyl)-dimethylcarbinol, 3-cyclohexyl-1-propanol, 2-cyclohexyl-1-propanol, 1-cyclohexyl-2-propanol, 2-cyclohexyl-1, 1-dimethylethanol, 2-cyclohexyl-2-methylpropanol, 2-cyclohexyl-1-methylpropanol, 2-cyclohexyl-1, 2-dimethylpropanol, 2-cyclohexyl-1, 1-dimethylpropanol, 3-cyclohexyl-2-methylpropanol, 3-cyclohexyl-1-methylpropanol, 3-cyclohexylbutanol, 3-cyclohexyl-2-methylbutanol and 3-cyclohexyl-1, 2-dimethylbutanol.
Dependencies are inferred from the claim text.