1,5-Benzodiazocines
AssigneeDDSA Pharmaceuticals
InventorUmakant Devdas Shenoy
Life of this patent
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Abstract
1,5-Benzodiazocines of the general formula ##STR1## their 5N-oxides, and acid addition salts thereof. In the above formula R.sub.1 =H, Halogen, CF.sub.3, --CN, --NO, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or C.sub.1-6 alkylthio; R.sub.2 =H, C.sub.1-6 alkyl or furyl; R.sub.3 =H, C.sub.1-6 alkyl, hydroxy-(C.sub.1-6 alkyl), C.sub.2-6 alkenyl or benzyl; and R.sub.4 =phenyl, (C.sub.1-6 alkyl)-phenyl, nitrophenyl, halophenyl or pyridyl. Also the production of such compounds from compounds of the benzodiazepine series.
Claims13
A 1,5-Benzodiazepine derivative of the general formula ##STR9## wherein R.sub.1 represents chlorine, a trifluoromethyl, cyano or nitro all in the 8 position;
- R.sub.2 represents a hydrogen atom or a lower alkyl group;
- R.sub.3 represents a hydrogen atom, a lower alkyl group, a hydroxy group, a lower alkenyl group or a benzyl group;
- and A represents a grouping of the general formula ##STR10## in which R.sub.4 represents a phenyl, (lower alkyl) phenyl, nitrophenyl or halophenyl;
- or a pharmaceutically acceptable acid addition salt thereof.
8-chloro-2-methylamino-6-phenyl-1,5-benzodiazocine-5-oxide.
8-chloro-4-methyl-2-methylamino-6-phenyl-1,5-benzodiazocine-5-oxide or a solvate thereof with methanol, ethanol or isopropanol.
8-chloro-4-ethyl-2-methylamino-6-phenyl-1,5-benzodiazocine-5-oxide.
8-chloro-4-propyl-2-methylamino-6-phenyl-1,5-benzodiazocine-5-oxide.
8-chloro-2-methylamino-6-phenyl-1,5-benzodiazocine-5-oxide hydrochloride.
8-chloro-4-methyl-2-methylamino-6-phenyl-1,5-benzodiazocine-5-oxide hydrochloride.
8-chloro-4-ethyl-2-methylamino-6-phenyl-1,5-benzodiazocine-5-oxide hydrochloride.
8-chloro-4-pyropyl-2-methylamino-6-phenyl-1,5-benzodiazocine-5-oxide hydrochloride.
Dependencies are inferred from the claim text.