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US 4,083,979 AGranted
Thiazolidine derivatives and their use as salidiuretics
AssigneeHoechst Aktiengesellschaft
InventorsHans-Jochen Lang, Roman Muschaweck
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Abstract
Diuretically active thiazolidine compounds and methods for making the same are disclosed, said compounds having an alkyl or alkenyl substituent in the 1-position, an imino group in the 2-position, and an hydroxy group and an N-acylated 3'-sulfamoylphenyl substituent in the 4-position, i.e. ##STR1##
Claims8
A thiazolidine compound of the formula ##STR92## and physiologically tolerated salts thereof, wherein R.sup.1 taken alone is alkyl or alkenyl having 1 to 4 carbon atoms;
- R.sup.2 taken alone is alkyl or alkenyl having 1 to 6 carbon atoms which may be substituted by alkoxy having 1 to 2 carbon atoms, by cycloalkyl having 3 to 8 carbon atoms, or by phenylalkyl having 1 or 2 carbon atoms in the alkyl;
- R.sup.1 and R.sup.2 taken together are 1,2-ethylene or 1,3-propylene;
- R.sup.3 is hydrogen, lower alkyl, or alkoxy having 1 to 3 carbon atoms, or is --NR.sup.4 R.sup.5 in which R.sup.4 and R.sup.5 taken alone are identical or different and each is hydrogen or lower alkyl having 1 to 4 carbon atoms, and if R.sup.5 is hydrogen then R.sup.4 may also by cycloalkyl having 5 to 8 carbon atoms, or in which R.sup.4 and R.sup.5 taken together with the nitrogen atom to which they are attached are pyrrolidine or piperidine;
- and Y is chlorine or bromine.
1 more element
Dependencies are inferred from the claim text.