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US 4,083,852 AGranted
Oxa- and thia-steroids
AssigneeShionogi & Co., Ltd.
InventorsTadao Terasawa, Toshihiko Okada
Life of this patent
Estimating the term…
Abstract
16-Oxa- and 16-thia-D-homo-estrogen derivatives useful as postcoital oral contraceptives which are produced by total synthesis from 1-vinyltetralin-1-ols or their thiuronium derivatives on reactions with 4-substituted tetrahydropyran- or tetrahydrothiopyran-3,5-diones, and subsequent appropriate modifications.
Claims18
A compound of the general formula:
- ##STR9## wherein R.sup.1 represents a lower alkyl of 1 - 5 carbon atoms, R.sup.2 represents a hydrogen atom or lower alkyl of 1 - 5 carbon atoms, R.sup.3 and R.sup.4, one of them represents a hydroxy or alkanoyloxy of 1 - 5 carbon atoms, and the other represents a hydrogen atom, lower alkyl of 1 - 5 carbon atoms, ethynyl or aralkyl of 7 - 8 carbon atoms, or taken together, may represent an oxo group, and X represents an oxygen atom or sulfur atom.
A compound of the general formula:
- ##STR10## wherein R.sup.1 represents a lower alkyl of 1 - 5 carbon atoms, R.sup.2 represents a hydrogen atom or lower alkyl of 1 - 5 carbon atoms, and X represents an oxygen atom or sulfur atom.
A compound of the general formula:
- ##STR11## wherein R.sup.1 represents a lower alkyl of 1 - 5 carbon atoms, R.sup.2 represents a hydrogen atom or lower alkyl of 1 - 5 carbon atoms, and R.sup.5 represents a hydrogen atom or alkanoyl of 1 - 5 carbon atoms, and X represents an oxygen atom or sulfur atom.
A compound of the general formula:
- ##STR12## wherein R.sup.1 represents a lower alkyl of 1 - 5 carbon atoms, R.sup.2 represents a hydrogen atom or lower alkyl of 1 - 5 carbon atoms, R.sup.6 represents a lower alkyl of 1 - 5 carbon atoms, ethynyl or aralkyl of 7 - 8 carbon atoms, and X represents an oxygen atom or sulfur atom.
Dependencies are inferred from the claim text.