Thymosin alpha 1
AssigneesBoard of Regents, The University of Texas, Hoffmann-La Roche Inc.
InventorsAllan L. Goldstein, Teresa L. K. Low, Chun-Yen Lai, Su-Sun Wang
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Abstract
The amino acid sequence of a biologically active polypeptide hormone isolated from calf thymus termed thymosin .alpha..sub.1 has been determined. Thymosin .alpha..sub.1 is a heat stable acidic molecule composed of 28 amino acid residues. This peptide is one of several present in thymosin fraction 5 which participate in the regulation, differentiation and function of thymic dependent lymphocytes (T cells).
Claims3
Thymosin .alpha..sub.1 being a polypeptide essentially free of other thymic polypeptides and having the following amino acid sequence:
- (N-acetyl)-Ser-Asp-Ala-Ala-Val.sup.5 -Asp-Thr-Ser-Ser-Glu.sup.10 -He-Thr-Thr-Lys-Asp.sup.15 -Leu-Lys-Glu-Lys-Lys.sup.20 -Glu-Val-Val-Glu-Glu.sup.25 -Ala-Glu-Asn-OH
- and the pharmaceutically acceptable acid addition salts or base salts thereof.
A method for reconstituting immune functions in thymic deprived or immunodeprived warm blooded mammals which method comprises administering to said mammal an immunopotentiating effective amount of thymosin .alpha..sub.1.
Dependencies are inferred from the claim text.