Thieno-pyridine derivatives and therapeutic composition containing same
AssigneeParcor
InventorJean-Pierre Maffrand
Life of this patent
Estimating the term…
Abstract
This invention relates to thieno-pyridine derivatives having the formula: ##STR1## in which R.sub.1 is hydrogen or alkyl having 1-6 carbon atoms; R.sub.2 is hydrogen or acetyl or lower alkylcarbamoyl and R.sub.3 is methyl, nitrobenzyl, chlorobenzyl, methoxybenzyl, chlorobenzoyl, trimethoxybenzoyl, pyrrolidinoacetyl, p.toluene-sulfonyl, phenylcarbamoyl, phenylthiocarbamoyl, 3-oxo-butyl, lower alkyl-carbamoyloxy, phenethyl, dichloroacetyl, 2-chlorophenoxy-2-methyl-propionyl or chlorophenyl-carbamoyl, and their pharmaceutically acceptable acid addition salts. Said derivatives have useful anti-inflammatory properties and inhibiting effects on blood plate aggregation which make them therapeutically valuable.
Claims4
A compound selected from the group consisting of the thieno-pyridine derivatives having the formulae ##STR3## in which R.sub.1 is selected from the group consisting of hydrogen and the alkyl groups having 1-6 carbon atoms;
- R.sub.2 is selected from the group consisting of hydrogen, acetyl and lower alkyl-carbamoyl;
- and R.sub.3 is selected from methyl, nitrobenzyl, chlorobenzyl, methoxybenzyl, chlorobenzoyl, trimethoxybenzoyl, pyrrolidinoacetyl, p.toluene-sulfonyl, phenylcarbamoyl, phenylthiocarbamoyl, 3-oxo-butyl, lower alkyl-carbamoyloxy, phenethyl, dichloroacetyl, 2-chlorophenoxy-2-methyl-propionyl and chlorophenyl-carbamoyl;
- and the pharmaceutically acceptable acid addition salts thereof.
Therapeutic composition having an anti-inflammatory activity and an inhibitor activity on blood plate aggregation, comprising an effective amount of a compound selected from the group consisting of the thieno-pyridine derivatives having the formulae:
- ##STR4## in which R.sub.1 is selected from the group consisting of hydrogen and the alkyl groups having 1-6 carbon atoms;
- R.sub.2 is selected from the group consisting of hydrogen, acetyl and lower alkyl-carbamoyl;
- and R.sub.3 is selected from the group consisting of oxybenzyl, chlorobenzoyl, trimethoxybenzoyl, pyrrolidinoacetyl, p.toluene-sulfonyl, phenylcarbamoyl, phenylthiocarbamoyl, 3-oxo-butyl, lower alkyl-carbamoyloxy, phenethyl, dichloroacetyl, 2-chlorophenoxy-2-methyl-propionyl and chlorophenyl-carbamoyl;
- and the pharmaceutically acceptable acid addition salts thereof, together with an inert pharmaceutical vehicle.
A thieno-pyridine derivative selected from the group consisting of 7-hydroxy-5-p.nitrobenzyl-4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine, 7-hydroxy-5-(3-oxo-butyl)-4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine, 7-acetoxy-5-o-chlorobenzyl-4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine, 7-hydroxy-5-methyl-4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine, 5-o-chlorobenzyl-7-hydroxy-4,5,6,7-tetrahydro-thieno [3,2-c]-pyridine, 7-hydroxy-5-o-nitrobenzyl-4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine, and the pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.