Aldehydes of the pregnane series and derivatives thereof
AssigneeCiba-Geigy Corporation
InventorsGeorg Anner, Charles Meystre
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Abstract
The derivatives of 1-dehydro-6.alpha.,9.alpha.-difluoro-16.alpha.-methyl-corticosterone having an aldehyde group in 21-position instead of the hydroxyl group, and derivatives of such aldehydes having a 2-chlorine atom, the corresponding hydrates, as well as their functional aldehyde derivatives, such as the acetals, display an antiinflammatory and thymolytic action. They are prepared by conventional methods.
Claims4
A 20-acylate of the .DELTA..sup.1,4,17(20) -16.alpha.-methyl-6.alpha.,9.alpha.-difluoro-11.beta.,20-dihydroxy-3,21-di oxo-pregnatriene, in which the acylate group is derived from a lower aliphatic carboxylic acid having from 1 to 7 carbon atoms.
A 20-acylate of the .DELTA..sup.1,4,17(20) -2-chloro-6.alpha.,9.alpha.-difluoro-16.alpha.-methyl- 11.beta.,20-dihydroxy-3,21-dioxo-pregnatriene, in which the acylate group is derived from a lower aliphatic carboxylic acid having from 1 to 7 carbon atoms.
Dependencies are inferred from the claim text.