US 4,075,340 A · Thieno [2,3-C] pyridine derivatives and therapeutic composition containing same

Abstract

This invention relates to derivatives having the formula: ##STR1## in which R.sub.1 is hydrogen or alkyl having 1-6 carbon atoms; X is (CHR.sub.2).sub.m in which m is an integer from 2 to 15, or (CHR.sub.2).sub.n R.sub.3 in which n is an integer from 1 to 15, R.sub.2 is hydrogen, or a hydroxy, acyloxy or alkyl group having 1-6 carbon atoms, and the various symbols R.sub.2 may have different meanings in each radical (CHR.sub.2) when several radicals (CHR.sub.2) are present, R.sub.3 is a trichloromethyl, acetyl, carboxy or alkoxycarbonyl group, or a phenyl, phenoxy, benzoyl, thienyl or pyridyl radical optionally substituted with at least a halogen atom, or a hydroxy, nitro, amino, cyano, carboxy, alkyloxycarbonyl, alkyl having 1-6 carbon atoms, alkoxy having 1-6 carbon atoms or methylenedioxy group, and to the acid addition salts of the derivatives of the formula (I). Said derivatives have useful anti-inflammatory and anti-arrhythmic activities and an inhibiting action on blood platelet aggregation.

Claims5

Dependent claims

A compound having the following structure:

##STR6## in which R.sub.1 is a member selected from the group consisting of hydrogen and methyl, with a proviso that when R.sub.1 is hydrogen, X is a member selected from the group consisting of
n-dodecyl,
o-methoxycarbonylbenzyl
o-carboxybenzyl
2-(5-chloro-thienyl)-methyl
2-acetoxy-2-p-chlorophenyl-ethyl
2-hydroxy-propyl
2-acetoxy-2-m.methoxyphenyl-ethyl
o-nitrobenzyl
p-nitrobenzyl
o-cyanobenzyl
2-chloro-benzyl
3,4,5-trimethoxy-benzyl
.beta.-phenethyl
m.methoxybenzyl
p.chlorobenzyl
m.chlorobenzyl
2-hydroxy-2-phenyl-ethyl
p.methylbenzyl
3,4-dimethoxy-benzyl
o.fluorobenzyl
2-hydroxy-2- p.chlorophenyl-ethyl
2,3,4-trimethoxy-benzyl
2-hydroxy-2-p.fluorophenyl-ethyl
2-hydroxy-2-p.methoxyphenyl-ethyl
2-hydroxy-3-p.methoxyphenoxy-propyl
3-oxo-butyl
2-hydroxy-3,3,3-trichloro-propyl
3,4-dimethoxy-benzyl
and when R.sub.1 is methyl, X is a member selected from the group consisting of
3,4,5-trimethoxy-benzyl
2-hydroxy-2-phenyl-ethyl
2-p.chlorophenyl-2-hydroxy-ethyl
o-chlorobenzyl
2-hydroxy-2-p.methoxyphenyl-ethyl
2-hydroxy-2-m.methoxyphenyl-ethyl
2-(2,4-dimethoxy-phenyl)-2-hydroxyethyl.

34 more elements

Dependencies are inferred from the claim text.

Thieno [2,3-C] pyridine derivatives and therapeutic composition containing same

Life of this patent

Thieno [2,3-C] pyridine derivatives and therapeutic composition containing same

Life of this patent

Abstract

Claims5