Vaccines, the process for preparing the same and the applications thereof
AssigneeAgence Nationale de Valorisation de la Recherche (ANVAR)
InventorEdgar Hans Relyveld
Life of this patent
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Abstract
This invention relates to a process for preparing vaccines, which consists in bringing into contact a toxic product with glutaraldehyde at a concentration and for a duration just sufficient to detoxify or inactivate said toxic product, and in stopping the glutaraldehyde-antigen reaction as soon as said inactivation stage is reached by physical and/or chemical means. The thus obtained inactivate product remaining antigenic and retaining its immunizing power, is usable as a vaccine for the preventive treatment of human and animals against infections caused for example by microbial or venomous toxins.
Claims26
An improvement in a process for preparing a bacterial vaccine by reacting whole bacteria with an inactivating agent and stopping the reaction as soon as said inactivation is achieved, wherein the improvement comprises the step of inactivating the whole bacteria with glutaraldehyde as the inactivating agent at a concentration ranging from about 0.00131 M to 0.0526 M, whereby an inactivated product is obtained which is usable as a bacterial vaccine while remaining antigenic and retaining its immunizing power.
Dependencies are inferred from the claim text.