Bronchospasmolytic phenylethanolamines
AssigneePharmacia Corporation
InventorKurt Hedegaard
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Abstract
Phenylethanolamines of the formula I ##STR1## wherein R is substituted phenyl or optionally substituted furyl, thienyl, or pyridyl, R.sub.5 is hydrogen, lower alkyl, or optionally substituted benzyl, R.sub.4, R.sub.6, R.sub.8, and R.sub.9 each are hydrogen or lower alkyl, R.sub.7 is hydrogen, halogen, or lower alkyl, Q is --CO--or --CH.sub.2 --, and L is hydrogen or lower alkylcarbonyl, and enantiomers, diastereoisomers and salts thereof; also, process for preparing the compounds. Compounds of the invention possess bronchosposmolytic activity.
Claims10
A phenylethanolamine of the formula ##STR25## wherein R is a substituted phenyl group of the formula ##STR26## wherein R.sub.1, R.sub.2, and R.sub.3 are the same or different and each represent hydrogen, hydroxy, halogen, trifluoromethyl, nitro, lower alkylcarbonyl, lower alkyl, lower alkoxy, hydroxy-lower alkyl, hydroxy-lower alkoxy, lower alkoxy-lower alkoxy, lower alkyl-carbonyl-lower alkoxy, or aryl-lower alkoxy, with the proviso that not all of R.sub.1, R.sub.2, and R.sub.3 are hydrogen, R.sub.4 is hydrogen or lower alkyl, R.sub.5 is hydrogen, lower alkyl, or optionally substituted benzyl, and R.sub.6 is hydrogen or lower alkyl, R.sub.7 is hydrogen, halogen, or lower alkyl, R.sub.8 is hydrogen or lower alkyl, R.sub.9 is hydrogen or lower alkyl, Q is --CH.sub.2 --, and L is hydrogen and enantiomers and, when more than one asymmetric carbon atom is present, also diastereoisomers, and physiologically acceptable salts thereof.
A pharmaceutical composition comprising a bronchospasmolytically effective amount of 3-(4-methoxybenzylamino)-4-hydroxy-.alpha.-(tert.butylaminomethyl)benzylal cohol or a salt thereof together with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.