Novel benzylalcohol derivatives as antidiabetics and cardiotonics
AssigneeTanabe Seiyaku Co., Ltd.
InventorsMuneyoshi Ikezaki, Nobuo Ito, Yasushi Okazaki, Masao Hoshiyama, Taku Nagao, Hiromichi Nakajima
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Abstract
A compound having the formula: ##STR1## wherein Ring A is monohydroxyphenyl, or a pharmaceutically acceptable acid addition salt thereof is prepared by catalytic hydrogenation of a compound having the formula: ##STR2## wherein A' is monobenzyloxyphenyl, and Y is carbonyl or hydroxymethylene. The compound (I) in which Ring A is 4-hydroxyphenyl or 3-hydroxyphenyl is useful as a cardiotonic agent. On the other hand, the compound (I) in which Ring A is 2-hydroxyphenyl is useful as an anti-diabetic agent.
Claims9
A pharmaceutical composition consisting essentially of an amount of a compound having the following formula:
- ##STR5## wherein Ring A is 4-hydroxyphenyl or a pharmaceutically acceptable acid addition salt thereof which is necessary to produce a cardiotonic effect by administration to a warm-blooded animal.
A pharmaceutical composition consisting essentially of an amount of a compound having the following formula:
- ##STR6## wherein Ring A is 2-hydroxyphenyl or a pharmaceutically acceptable acid addition salt thereof which is necessary to produce an anti-diabetic effect by administration to a warm-blooded animal.
A method of producing a cardiotonic effect on a warm-blooded animal comprising administering to said warm-blooded animal an effective amount of a compound having the formula ##STR7## wherein Ring A is 4-hydroxyphenyl.
A method of producing an anti-diabetic effect on a warm-blooded animal comprising administering to said warm-blooded animal an effective amount of a compound having the formula ##STR8## wherein Ring A is 2-hydroxyphenyl.
Dependencies are inferred from the claim text.