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US 4,072,756 AGranted
Tricyclo piperidino ketones and soporific compositions thereof
AssigneeSandoz Ltd.
InventorsAnton Ebnother, Jean-Michel Bastian, Fulvio Gadient, Andre Stoll
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Abstract
The invention concerns novel compounds of the formula: ##STR1## wherein n is 1, 2 or 3 R.sub.1 is lower alkyl R.sub.2 is hydrogen or lower alkyl and A is a tricyclic moiety, Useful as sedative-neuroleptic, muscle-relaxant and sleep-promoting agents.
Claims29
A compound of the formula, ##STR13## wherein n is 1, 2 or 3,
- R.sub.1 is lower alkyl,
- R.sub.2 is hydrogen or lower alkyl,
- R.sub.3 is hydrogen, chlorine, bromine, fluorine, trifluoromethyl, lower alkyl, lower alkoxy or lower alkylthio,
- A and B together with the double bond form a benzene ring, or a benzene ring substituted by chlorine, bromine, fluorine, trifluoromethyl, lower alkyl, lower alkoxy or lower alkylthio, or
- A is sulphur and
- A and B together with the double bond form a thiophene ring, or a thiophene ring substituted in the .alpha. position to the sulphur by chlorine, bromine or lower alkyl, and
- Y is ethylene or vinylene, when A and B together with the double bond form a benzene ring, or a benzene ring substituted by chlorine, bromine, fluorine, trifluoromethyl, lower alkyl, lower alkoxy or lower alkylthio, or when A is sulphur and A and B together with the double bond form a thiophene ring, or a thiophene ring substituted in the .alpha. position to the sulphur by chlorine, bromine or lower alkyl, or
- Y is oxygen, methyleneoxy, methylenethio or a group ##STR14## wherein R.sub.4 and R.sub.5 are independently lower alkyl, when A and B together with the double bond form a benzene ring, or a benzene ring substituted by chlorine, bromine, fluorine, trifluoromethyl, lower alkyl, lower alkoxy or lower alkylthio, or
- Y is sulphur, when A is sulphur and A and B together with the double bond form a thiophene ring,
- or a pharmaceutically acceptable acid addition salt thereof.
7 more elements
Dependencies are inferred from the claim text.