Novel cyclopentanoic acid derivatives
AssigneeRoussel Uclaf
InventorsJean Buendia, Michel Vivat, Jeanine Schalbar
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AssigneeRoussel Uclaf
InventorsJean Buendia, Michel Vivat, Jeanine Schalbar
Estimating the term…
Novel cyclopentanoic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## and --CH.sub.2 OH, R' is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and a non toxic, pharmaceutically acceptable cation and R.sub.1 is selected from the group consisting of hydrogen, 2-tetrahydropyranyl, branched or straight chain, saturated or unsaturated alkyl of 1 to 4 carbon atoms and ##STR3## and R.sub.2 is selected from the group consisting of straight or branched chain alkyl of 1 to 12 carbon atoms and phenyl with the alkyl and phenyl being optionally substituted with --COOA wherein A is selected from the group consisting of hydrogen, alkali metal, ammonium ion, ion of an organic amine, alkyl and haloalkyl of 1 to 7 alkyl carbon atoms with the proviso that R.sub.1 is not hydrogen or 2-tetrahydropyranyl when R is a carboxylic group, and the OH and R groups on the ring and OR.sub.1 group on the chain may be in either of the two possible positions about the carbon atom to which they are attached having analgesic, anti-inflammatory and smooth muscle relaxant activity.
A compound of the formula ##STR17## wherein R is ##STR18## R' is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and a non-toxic, pharmaceutically acceptable cation and R.sub.1 is selected from the group consisting of branched or straight chain, saturated or unsaturated alkyl of 1 to 4 carbon atoms and ##STR19## and R.sub.2 is selected from the group consisting of straight or branched chain alkyl of 1 to 12 carbon atoms and phenyl with the alkyl and phenyl being optionally substituted with --COOA wherein A is selected from the group consisting of hydrogen, alkali metal, ammonium ion, ion of an organic amine, alkyl and haloalkyl of 1 to 7 alkyl carbon atoms and the OH and R groups on the ring and OR.sub.1 group on the chain may be in either of the two possible positions about the carbon atom to which they are attached.
Dependencies are inferred from the claim text.