Hydratropic acid derivatives and process for the production thereof
AssigneeMerck Patent GmbH
InventorsErich Schacht, Werner Mehrhof, Zdenek Simane, Herbert Nowak, Detlev Kayser
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AssigneeMerck Patent GmbH
InventorsErich Schacht, Werner Mehrhof, Zdenek Simane, Herbert Nowak, Detlev Kayser
Estimating the term…
Hydratropic acid derivatives of the formula ##STR1## wherein R.sub.1 is H, alkyl of 1-4 carbon atoms, 2-acetamidoethyl, 1-methyl-4-piperidyl, or 2,3-dihydroxypropyl, and R.sub.2 is Hal, phenyl, 4-Hal-phenyl, 4-Hal-phenoxy, 4-Hal-phenoxymethyl, 1,2,3,4-tetrahydro-1-naphthyl, 1-pyrryl, piperidino, isoindolino, 1,2,3,4-tetrahydroquinolino, 1,2,3,4-tetrahydro-4-quinolyl or 1-methyl-1,2,3,4-tetrahydro-4-quinolyl, Hal being F, Cl, or Br, and the physiologically acceptable salts thereof, which possess cholesterol and triglyceride serum-level-lowering activity, can be prepared by reacting a phenol of the formula ##STR2## with a compound of the formula X--C(CH.sub.3)(C.sub. 6 H.sub.5)--COOR.sub.1 wherein X represents Cl, Br, I, OH, or esterified OH.
A hydratropic acid derivative of the formula ##STR8## wherein R.sub.1 is H, alkyl of 1-4 carbon atoms, 2-acetamidoethyl, or 2,3-dihydroxypropyl, and R.sub.2 is Hal, phenyl, 4-Hal-phenyl, 4-Hal-phenoxy, 4-Hal-phenoxymethyl, 1,2,3,4-tetrahydro-1-naphthyl, Hal being F, Cl, or Br, or a physiologically acceptable salt thereof with an acid or base.
Dependencies are inferred from the claim text.