Pharmaceutical method for the therapy of immune diseases
AssigneeZaidan Hojin Biseibutsu Kagaku Kenkyu Kai
InventorsHamao Umezawa, Tomio Takeuchi, Akira Takamatsu, Shunro Mori
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Abstract
Compounds having the formula ##STR1## (the meanings of R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are indicated hereinafter) exhibit suppressive activity to various immune responses and can be employed in the therapy of immunological diseases, especially autoimmune diseases. One example is 3',5'-dichloro-2,4'-diacetoxybenzanilide having the formula ##STR2## and another is 3',5'-dichloro-2,4'-dibenzoyloxyanilide having the formula ##STR3##
Claims12
The method for chemotherapeutically treating immune diseases and disorders which comprises administering to a living animal a pharmaceutical composition to suppress the immune response comprising an effective amount of a suppressing compound of the formula ##STR16## wherein R.sup.1 is --O--CO--Y with Y being a lower alkyl or phenyl group;
- R.sup.2 is hydrogen, chlorine, fluorine, trifluoromethyl or lower alkyl;
- R.sup.3 and R.sup.5 are hydrogen, fluorine, bromine, chlorine, nitro, or lower alkyl;
- and
- R.sup.4 is substituted at either the 2' or 4' position and is --O--CO--Y, Y meaning the same as noted above and lower alkyl as used herein is a straight or branched chain saturated hydrocarbon with 1 to 4 carbon atoms in combination with a pharmaceutically acceptable nontoxic carrier.
The method for chemotherapeutically treating immune diseases and disorders which comprises administering to a living animal a pharmaceutical composition to suppress the immune response comprising an effective amount of a suppressing compound of the formula ##STR17## wherein R.sup.1 is --O--CO--Y with Y being a lower alkyl or phenyl group;
- R.sup.2 is hydrogen, chlorine, fluorine, trifluoromethyl or lower alkyl;
- R.sup.3 and R.sup.5 are hydrogen, fluorine, bromine, chlorine, nitro, or lower alkyl;
- and
- R.sup.4 is --O--CO--Y, Y meaning the same as noted above, and lower alkyl as used herein is a straight or branched chain saturated hydrocarbon with 1 to 4 carbon atoms in combination with a pharmaceutically acceptable nontoxic carrier.
Dependencies are inferred from the claim text.