Phenylmethylphenoxy propionic acid esters
AssigneeOrchimed SA
InventorAndre Mieville
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Abstract
Compounds of the formula ##STR1## in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X.sub.4 and X.sub.5 are hydrogen or lower alkyl, Y is hydrogen, hydroxy, etherified hydroxy, substituted amino, or N-attached heterocyclyl, X.sub.0 is O or OCH.sub.2 CH.sub.2 O, R' represents hydrogen, lower alkyl or acetyl; and acid-addition salts thereof, are novel and useful in pharmacy as hypolipaemiant, hypocholesterolaemiant and cholagogic agents or in the preparation of such agents.
Claims8
A compound of the formula:
- ##STR227## wherein A is ##STR228## and X.sub.1, X.sub.2 and X.sub.3 are the same or different and are H, Cl, Br, F;
- Y is OH or alkoxy;
- each of R, X.sub.4 and X.sub.5 is hydrogen or C.sub.1-4 alkyl;
- R' is H, C.sub.1-4 alkyl or acetyl;
- or an acid addition salt thereof.
2-[ 4-(.alpha.-p-Nitrophenyl-.alpha.-hydroxy)-methyl)-methyl-phenoxy]-2-methylp ropionic acid.
A pharmaceutical composition for the treatment of hyperlipaemia comprising a therapeutically active amount of a compound as claimed in claim 20 or a non-toxic acid-addition salt thereof, and a physiologically acceptable pharmaceutical excipient.
Dependencies are inferred from the claim text.