3-(3',4'-Disubstituted) phenyl piperidines
AssigneeRoussel Uclaf
InventorsLucien Nedelec, Jacques Guillaume, Claude Dumont
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Abstract
Novel phenyl piperidines of the formula ##STR1## wherein X is selected from the group consisting of hydrogen and acyl of an aliphatic carboxylic acid of 2 to 6 carbon atoms and R is selected from the group consisting of alkyl of 1 to 5 carbon atoms, alkenyl of 2 to 5 carbon atoms and phenyl alkyl of 1 to 3 alkyl carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having dopaminergic properties and certain of the compounds possess hypotensive properties.
Claims18
A compound selected from the group consisting of a compound of the formula ##STR9## wherein X is selected from the group consisting of hydrogen and acyl of an alkanoic acid of 2 to 6 carbon atoms and R is selected from the group consisting of alkyl of 1 to 5 carbon atoms, alkenyl of 2 to 5 carbon atoms and phenylalkyl of 1 to 3 alkyl carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts.
An hypotensive composition comprising an hypotensively effective amount of at least one compound selected from the group consisting of N-benzyl-3-(3',4'-diacetoxyphenyl)-piperidine and N-(.beta.-phenethyl)-3-(3',4'-dihydroxyphenyl)-piperidine and their non-toxic, pharmaceutically acceptable acid addition salts.
A method of inducing hypotensive activity in warm-blooded animals comprising administering to warm-blooded animals an hypotensively effective amount of at least one compound selected from the group consisting of N-benzyl-3-(3',4'-diacetoxyphenyl)-piperidine and N-(.beta.-phenethyl)-3-(3',4'-dihydroxyphenyl)-piperidine and their non-toxic, pharmaceutically acceptable acid addition salts.
Dependencies are inferred from the claim text.