New 1-(2'-aroyl eth-1' yl) 2-(4"-acetamido piperazine-1" yl methyl) benzimidazoles, their therapeutical applications and method for their preparation

Abstract

Compounds of the formula ##STR1## where Ar is phenyl, substituted phenyl, .alpha.-furyl or .alpha.-thienyl, and R is NH.sub.2, NHR.sup.1 wherein R.sup.1 is alkyl or cycloalkyl, or NR.sub.1 R.sub.2 wherein R.sub.1 and R.sub.2 are alkyl or --N.sub.1 R.sub.1 R.sub.2 is piperidino, pyrrolidino, morpholino or hexamethyleneimino. The compounds are prepared by reacting the corresponding Ar-substituted chloromethylated benzimidazole with the corresponding R-substituted piperazine. The compounds possess gastric antisecretory, anti-ulcerous, spasmolytic, anti-cholinergic, anti-bronchoconstrictive, analgesic, anti-inflammatory, anti-hypertensive and diuretic properties.

Dependencies are inferred from the claim text.