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US 4,072,679 AGranted
1,4- AND 4,10-DIHYDRO-4-OXO-PYRIMIDO (1,2-A)-benzimidazole-3-carboxylic acids, esters and amides
AssigneeE. R. Squibb & Sons, Inc.
InventorsTheodor Denzel, Hans Hoehn
Life of this patent
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Abstract
New derivatives, and their salts, of 1,4- and 4,10-dihydro-4-oxo-pyrimido[1,2-a]benzimidazole-3-carboxylic acids, esters and carboxamides have the general formulas ##STR1## They are useful as central nervous system depressants and anti-inflammatory agents.
Claims18
A compound of the formula ##STR93## wherein R.sup.1 is hydrogen, lower alkyl, phenyl-lower alkyl or lower alkyl ##STR94## R.sup.2 is hydrogen or lower alkyl;
- R.sup.3 is hydroxy, lower alkoxy or ##STR95## R.sup.4 and R.sup.5 each is lower alkyl;
- R.sup.6 and R.sup.7 each is hydrogen, lower alkyl, phenyl, substituted phenyl wherein the phenyl substituent is halo, lower alkyl or lower alkoxy or phenyllower alkyl;
- and physiologically acceptable salts thereof.
Dependencies are inferred from the claim text.