LH-RH Analogs
AssigneeThe Salk Institute for Biological Studies
InventorsMax S. Amoss, Michael W. Monahan, Wylie W. Vale, Jr.
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Abstract
Peptides have been synthesized which influence the secretion of gonadotropins by the pituitary gland of mammalians, including humans. Some of the peptides promote the release of gonadotropins, while other peptides inhibit the release.
Claims7
A peptide which influences the release of gonadotropins by the pituitary gland, said peptide being pGlu-R.sub.1 -Trp-Ser-Tyr-R.sub.2 -Leu-Arg-Pro-Gly-NH.sub.2 wherein R.sub.1 is either deleted or selected from His, Gly, Asp, Cys and D-Ala and R.sub.2 is D-Ala.
A peptide which influences the release of gonadotropins by the pituitary gland, said peptide being pGlu-R.sub.1 -Trp-Ser-Tyr-R.sub.2 -Leu-Arg-Pro-NHCH.sub.2 CH.sub.2 CH.sub.3 wherein R.sub.1 is either deleted or selected from His, Gly, Asp, Cys, and D-Ala and R.sub.2 is D-Ala.
Dependencies are inferred from the claim text.