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US 4,071,683 AGranted
Oxoimidazolidinylthiocarbonyl derivatives of ceph-3-em-4-carboxylic acids
AssigneeBayer Aktiengesellschaft
InventorsHans-Bodo Konig, Karl Georg Metzger, Wilfried Schrock
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Abstract
.beta.-Lactams of the formula ##STR1## and pharmaceutically acceptable nontoxic salts thereof wherein A is hydrogen or alkyl of 1 to 4 carbon atoms; B is phenyl, methylphenyl, chlorophenyl, hydroxyphenyl or cyclohexa-1,4-dien-1-yl; R is a moiety of the formula ##STR2## wherein E is hydrogen, --OH or --O--CO--CH.sub.3 ; and C constitutes a center of chirality; Are produced which exhibit antibiotic activity.
Claims10
A compound selected from the group consisting of a cephalosporin of the formula:
- ##STR20## and the pharmaceutically acceptable salts thereof wherein the carbon atom designated C constitutes a center of chirality;
- A is hydrogen or alkyl of 1 to 4 carbon atoms;
- B is phenyl, methylphenyl, chlorophenyl, hydroxyphenyl or cyclohexa-1,4-dien-1-yl;
- and
- E is hydrogen, hydroxy or acetoxy.
2 more elements
Dependencies are inferred from the claim text.