1-Substituted-amino-3-(4-furo[3,2-c]pyridinyloxy)-2-propanols
AssigneeSandoz Ltd.
InventorsErik Wiskott, Franz Troxler
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AssigneeSandoz Ltd.
InventorsErik Wiskott, Franz Troxler
Estimating the term…
This invention provides new compounds of formula I, ##STR1## wherein R is alkyl of 3 to 7 carbon atoms or cycloalkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms monosubstituted by alkyl of 1 to 4 carbon atoms, .alpha.-dialkylpropynyl of 5 to 9 carbon atoms or .alpha.-dialkyl-allyl of 5 to 9 carbon atoms, hydroxyalkyl of 2 to 7 carbon atoms or phenoxyalkyl of 8 to 11 carbon atoms, the oxygen atom of the last two radicals being separated by at least two carbon atoms from the nitrogen atom to which R is bound, R.sub.1 is I. hydrogen or alkyl of 1 to 4 carbon atoms in the 2,3,6 or 7 position, or Ii. chlorine or bromine, in the 2, 3 or 7 position, Iii. nitro or --NHA wherein A is alkanoyl of 1 to 4 carbon atoms, in the 2, 3 or 7 position, or Iv. fluorine, cyano or COOB, wherein B is alkyl of 1 to 4 carbon atoms, in the 2 or 3 position, and R.sub.2 is I. hydrogen or alkyl of 1 to 4 carbon atoms in the 2, 3, 6 or 7 position, Ii. chlorine or bromine, in the 2, 3 or 7 position, or Iii. fluorine in the 2 or 3 position, useful in the treatment of heart diseases.
A racemic or optically active compound of formula I, ##STR14## wherein R is alkyl of 3 to 7 carbon atoms or cycloalkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms monosubstituted by alkyl of 1 to 4 carbon atoms, .alpha.-dialkylpropynyl of 5 to 9 carbon atoms or .alpha.-dialkyl-allyl of 5 to 9 carbon atoms, hydroxyalkyl of 2 to 7 carbon atoms or phenoxyalkyl of 8 to 11 carbon atoms, the oxygen atom of the last two radicals being separated by at least two carbon atoms from the nitrogen atom to which R is bound,
A compound of claim where R is other than phenoxy-alkyl, R.sub.1 is hydrogen or alkyl in the 2, 3, 6 or 7 position, or chlorine or bromine in the 2, 3 or 7 position, or fluorine, cyano or COOB wherein B is alkyl of 1 to 4 carbon atoms, in the 2 or 3 position, or nitro in the 7 position.
Dependencies are inferred from the claim text.