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US 4,071,553 AGranted
Method for the production of trans-4-aminomethyl cyclohexane-1-carboxylic acid
AssigneeKureha Kagaku Kogyo Kabushiki Kaisha
InventorsMasaaki Takahashi, Akira Iizuka, Kiro Asano
Life of this patent
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Abstract
Disclosed is a method for producing trans-4-aminomethyl cyclohexane-1-carboxylic acid by heating and isomerizing cis-4-aminoethyl cyclohexane-1-carboxylic acid hydrochloride or a mixture of cis-4-aminomethyl cyclohexane-1-carboxylic acid hydrochloride with trans-4-aminomethyl cyclohexane-1-carboxylic acid hydrochloride in an atmosphere of hydrogen chloride gas and in the absence of a solvent.
Claims2
A method for the production of trans-4-aminomethyl cyclohexane-1-carboxylic acid, which comprises:
- a. thermally melting cis-4-aminomethyl cyclohexane-1-carboxylic acid hydrochloride or a mixture of cis-4-aminomethyl cyclohexane-1-carboxylic acid hydrochloride and trans-4-aminomethyl cyclohexane-1-carboxylic acid hydrochloride without a solvent in an atmosphere of hydrogen chloride gas at a temperature in the range of from 160.degree. C to 248.degree. C, to convert the cis-4-aminomethyl cyclohexane-1-carboxylic acid hydrochloride into trans-4-aminomethyl cyclohexane-1-carboxylic acid hydrochloride;
- and
- b. subsequently dehydrochlorinating the trans-4-aminomethyl cyclohexane-1-carboxylic acid hydrochloride.
Dependencies are inferred from the claim text.