Aryloxy aminobutanols, their preparation and use thereof
AssigneeAyerst McKenna and Harrison Ltd.
InventorsJean-Marie Ferland, Real Laliberte, Wilbur Lippmann, Thomas A. Pugsley
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Abstract
Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
Claims15
A compound of Formula 1 ##STR5## in which Ar is phenyl or 1-naphthyl;
- R.sup.1 is hydrogen or lower alkyl;
- and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl having 1-2 carbons;
- with the proviso that when Ar is 1-naphthyl then ##STR6## is selected from the group consisting of amino, ethylamino and dimethylamino;
- and with the proviso that when Ar is phenyl then ##STR7## is methylamino;
- and with the further proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl;
- or a therapeutically acceptable acid addition salt thereof.
2-(Methylamino)-4-(1-naphthyloxy)-1-butanol.
2-(Methylamino)-4-(1-naphthyloxy)-1-butanol maleate.
2-(Ethylamino)-4-phenoxy-1-butanol.
2-(Ethylamino)-4-phenoxy-1-butanol hydrochloride.
Dependencies are inferred from the claim text.