US 4,071,536 AGranted

Antibiotics

AssigneeBeecham Group Limited

InventorsKevin David Barrow, Graham Mellows

Life of this patent

Estimating the term…

Abstract

An active antibacterial substance from Pseudomonas fluorescens bacterium designated pseudomonic acid and as a coproduct a minor amount of a compound having an additional OH group designated as pseudomonic acid I. These two substances obtained are separated and purified. Alkali metal salts and methyl esters can be prepared. The antibacterial activity of pseudomonic acid appears to reside in the free acid from which results from in vivo hydrolysis of the methyl ester which is crystalline.

Claims4

Dependent claims

A compound which is the free acid form of pseudomonic acid having the formula (I) or an alkali metal salt or methyl ester of the carboxylic acid group thereof :

##STR5## , the double bond being in the trans-configuration.

Dependencies are inferred from the claim text.

Facts

Application: 05/684,077Filed 7 May 1976 · continuation in part
Priority: UK 27653/7112 Jun 1971
Granted: 31 Jan 1978
Term ends: Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07D 407/06
Containing two hetero rings: linked by a carbon chain containing only aliphatic carbon atoms
A61K 31/19
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids: carboxylic acids, e.g. valproic acid
C07D 309/10
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…
C12P 17/06
Oxygen as only ring hetero atoms: containing a six-membered hetero ring, e.g. fluorescein

Family

Serial261,042Parent of this continuation-in-part · filed 8 Jun 1972
Serial463,197Parent of this continuation-in-part · filed 22 Apr 1974
US 4,071,536 AThis patent

From the US filing history. Foreign family members aren’t listed.

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